Недавно получил важное письмо от Линди Кунц (Австрийский Клуб БЗ)
Fw: A genetic "pre-test" for Histiocytic sarcoma in Bernese Mountain dogs
От кого: "Lindy Kunz" <lindykunz@email.com>
Кому: SERGEM <SERGEM@MAIL.RU>
Maybe Margret has already sent you this amazing exciting news.
I got such wonderful photos of your Sennen Festival from Teresa Deik. She makes excellent photos with a lot of atmosphere. Would you like me to send them to you?
Anyway your Festival was apparently a wonderful success. Now I wish so much that I had been there instead of sitting in Austria in the rain and floods. But I have my little puppy now 16 weeks old so I could not have gone anyway.
Please could you put the news about this preliminary gene test on your website and also mention that they desparately need more blood samples from all over the world to be able to norm this test for countries other than France. I personally am sure that the Bernese population all over the world has the same genome but these people in Rennes are such exact scientists, they want to norm this test in every country in Europe if possible!
Please send me a link to your Festival where I can see more photos.
Lindy
----- Original Message -----
From: Catherine André
Sent: 06/24/13 02:12 PM
To: Silvana Vogel Tedeschi, info@bernertenno.it , Petra Reutzel, Claudia - vom Freisingerland, bachmann@ssv-ev.de , Lindy Kunz, Terrill Eckert, Margret Bärtschi, klingeborn@tele2.se , Joël Van Haute, cehrs martha, Antonio Indrizzi, devael de Berna Boyeros, green Stephen, Bibby Bibby, Armando Azevedo, Moinhos d'Alvura, djagielski@poczta.onet.pl , Geissbuehler Urs, us_kbs@bluewin.ch , Urs (VETSUISSE) Geissbühler, Maret' 'Andrea, simona, andrea.maret@sunrise.ch , Deloyce Conrad, joel.van.haute@telenet.be
Subject: A genetic "pre-test" for Histiocytic sarcoma in Bernese Mountain dogs
Dear all,
So far, so long, … working hard on the genetics of Histiocytic Sarcoma … years passed since we met, for most of you in England at the International BMD seminar, organized by Steve Green and/or at the symposium organized by Sylvana Vogel Tedeschi, or even before ....
We are happy to let you know that we developed a genetic risk "pre-test" for Histiocytic sarcoma in the Bernese Mountain dog populations (see below).
The genetic markers and statistical analysis have been elaborated by Benoit Hedan in our team, mainly with data and samples from French Bernese Mountain Dogs and in this context, the next step will be to validate this test in other european populations.
To inform european Bernese Mountain clubs, we sent this e-mail to our contacts (present and previous), but we do not have systematically the "health" contact / President for all European Clubs, please pass on our message and we do of course apologize for those who are not on the first list.
We hope this e-mail finds you well and we wish you all the best.
Catherine André & Benoit Hedan
Information to European Bernese Mountain dogs (BMD) Clubs and Societies
The “Dog genetics team” of CNRS of Rennes and ANTAGENE laboratory (France) have worked together to provide breeders with a first genetic "pre-test" to estimate the risk of developing and transmitting histiocytic sarcoma in Bernese Mountain Dogs (BMD). We expect that this tool will help breeders to progressively reduce the frequency of histiocytic sarcoma in BMDs.
Following several years of international collaborative research histiocytic sarcoma*;
- at CNRS (Rennes, France), we considered that the first genetic results could be used to provide breeders with a pre-test, usefull for selection in their kennel. Using genetic and genealogical data from over 1000 BMDs, mostly from France, we selected nine markers, which allow to estimate a risk in the context of a kennel. We validated their use with the recent collaboration of the French BMD club (AFBS) and several French breeders.
Presently this pre-test is exclusively available to BMDs breeders and validated for BMDs of the French population. This pre-test is intended to help breeders in their selection and should be used as a selection factor among others (Hip dysplasia, beauty, behaviour, other health characteristics…). It is not a predictive test for histiocytic sarcoma on single dogs. The correct use of this pre-test, on males and females for reproduction as well as puppies to select the best offsprings for the next generation, aims to help breeders to adapt their breeding programs, to reduce the risk of developing and transmitting histiocytic sarcoma in their breeding lines, and more widely, the incidence of this cancer in the population of BMDs.
To validate this DNA pre-test on several European populations of BMDs, in order to enlarge its use to other BMD populations, we need the involvement of BMD clubs from each country. Thus, we‘re asking your help to inform breeders and to collect blood samples (5ml on EDTA tubes) of 30 old healthy BMDs (> 10 years old) and 30 affected BMDs from your country.
Should you require any further information, please do not hesitate to contact us (Benoit and /or myself).
* The collaborative research is performed since many years between the “dog genetics team”, CNRS (Centre National de la Recherche Scientifique of Rennes, France) and international teams of Dr. Elaine Ostrander (NIH, National Institutes of Health, U.S.) and Dr. Matthew Breen (NCSU, U.S.), thanks to the financial support of the AKC-CHF, of the French BMD club (AFBS), the SIBB Italian Club and the DCBS German Club.
Sincerely,
Catherine André and Benoit Hedan
Dog genetics team, CNRS Rennes, France
Dr. Catherine André
Equipe "Génétique du chien"
"Institut de Génétique et Développement de Rennes"
UMR6290-CNRS, Université de Rennes 1
2, Av. Léon Bernard
35043 Rennes cedex
Tel +33 (0)2 23 23 45 09 / 41 75
Fax : +33 (0)2 23 23 44 78
catherine.andre@univ-rennes1.fr
Site du laboratoire : http://igdr.univ-rennes1.fr/
Site "Génétique du chien" : http://dog-genetics.genouest.org
Вкратце
Во Франции удалось создать тест на проверку вероятности заболевания раком Берснских Зенненхундов.
Тест отработан на французском поголовье Бернов.
Французские исследователи-ученые обращаются за помощью ко всем Клубам БЗ мира - собрать образцы крови Бернов и выслать их во Францию для отработки теста для всех Бернов мира.
Иными словами, можно будет сдать кровь, и по крови ученые смогут сказать о вероятности заболевания раком конкретной собаки.
Как вы понимаете, это имеет исключительную важность для дальнейшего разведения породы с учетом повышения продолжительности жизни.
Как нам это сделать в России?? Я пока не знаю. Надо думать всем вместе!
Готов перевести те предложения, которые остались непонятными. Но суть письма я уже передал.
Fw: A genetic "pre-test" for Histiocytic sarcoma in Bernese Mountain dogs
От кого: "Lindy Kunz" <lindykunz@email.com>
Кому: SERGEM <SERGEM@MAIL.RU>
Maybe Margret has already sent you this amazing exciting news.
I got such wonderful photos of your Sennen Festival from Teresa Deik. She makes excellent photos with a lot of atmosphere. Would you like me to send them to you?
Anyway your Festival was apparently a wonderful success. Now I wish so much that I had been there instead of sitting in Austria in the rain and floods. But I have my little puppy now 16 weeks old so I could not have gone anyway.
Please could you put the news about this preliminary gene test on your website and also mention that they desparately need more blood samples from all over the world to be able to norm this test for countries other than France. I personally am sure that the Bernese population all over the world has the same genome but these people in Rennes are such exact scientists, they want to norm this test in every country in Europe if possible!
Please send me a link to your Festival where I can see more photos.
Lindy
----- Original Message -----
From: Catherine André
Sent: 06/24/13 02:12 PM
To: Silvana Vogel Tedeschi, info@bernertenno.it , Petra Reutzel, Claudia - vom Freisingerland, bachmann@ssv-ev.de , Lindy Kunz, Terrill Eckert, Margret Bärtschi, klingeborn@tele2.se , Joël Van Haute, cehrs martha, Antonio Indrizzi, devael de Berna Boyeros, green Stephen, Bibby Bibby, Armando Azevedo, Moinhos d'Alvura, djagielski@poczta.onet.pl , Geissbuehler Urs, us_kbs@bluewin.ch , Urs (VETSUISSE) Geissbühler, Maret' 'Andrea, simona, andrea.maret@sunrise.ch , Deloyce Conrad, joel.van.haute@telenet.be
Subject: A genetic "pre-test" for Histiocytic sarcoma in Bernese Mountain dogs
Dear all,
So far, so long, … working hard on the genetics of Histiocytic Sarcoma … years passed since we met, for most of you in England at the International BMD seminar, organized by Steve Green and/or at the symposium organized by Sylvana Vogel Tedeschi, or even before ....
We are happy to let you know that we developed a genetic risk "pre-test" for Histiocytic sarcoma in the Bernese Mountain dog populations (see below).
The genetic markers and statistical analysis have been elaborated by Benoit Hedan in our team, mainly with data and samples from French Bernese Mountain Dogs and in this context, the next step will be to validate this test in other european populations.
To inform european Bernese Mountain clubs, we sent this e-mail to our contacts (present and previous), but we do not have systematically the "health" contact / President for all European Clubs, please pass on our message and we do of course apologize for those who are not on the first list.
We hope this e-mail finds you well and we wish you all the best.
Catherine André & Benoit Hedan
Information to European Bernese Mountain dogs (BMD) Clubs and Societies
The “Dog genetics team” of CNRS of Rennes and ANTAGENE laboratory (France) have worked together to provide breeders with a first genetic "pre-test" to estimate the risk of developing and transmitting histiocytic sarcoma in Bernese Mountain Dogs (BMD). We expect that this tool will help breeders to progressively reduce the frequency of histiocytic sarcoma in BMDs.
Following several years of international collaborative research histiocytic sarcoma*;
- at CNRS (Rennes, France), we considered that the first genetic results could be used to provide breeders with a pre-test, usefull for selection in their kennel. Using genetic and genealogical data from over 1000 BMDs, mostly from France, we selected nine markers, which allow to estimate a risk in the context of a kennel. We validated their use with the recent collaboration of the French BMD club (AFBS) and several French breeders.
Presently this pre-test is exclusively available to BMDs breeders and validated for BMDs of the French population. This pre-test is intended to help breeders in their selection and should be used as a selection factor among others (Hip dysplasia, beauty, behaviour, other health characteristics…). It is not a predictive test for histiocytic sarcoma on single dogs. The correct use of this pre-test, on males and females for reproduction as well as puppies to select the best offsprings for the next generation, aims to help breeders to adapt their breeding programs, to reduce the risk of developing and transmitting histiocytic sarcoma in their breeding lines, and more widely, the incidence of this cancer in the population of BMDs.
To validate this DNA pre-test on several European populations of BMDs, in order to enlarge its use to other BMD populations, we need the involvement of BMD clubs from each country. Thus, we‘re asking your help to inform breeders and to collect blood samples (5ml on EDTA tubes) of 30 old healthy BMDs (> 10 years old) and 30 affected BMDs from your country.
Should you require any further information, please do not hesitate to contact us (Benoit and /or myself).
* The collaborative research is performed since many years between the “dog genetics team”, CNRS (Centre National de la Recherche Scientifique of Rennes, France) and international teams of Dr. Elaine Ostrander (NIH, National Institutes of Health, U.S.) and Dr. Matthew Breen (NCSU, U.S.), thanks to the financial support of the AKC-CHF, of the French BMD club (AFBS), the SIBB Italian Club and the DCBS German Club.
Sincerely,
Catherine André and Benoit Hedan
Dog genetics team, CNRS Rennes, France
Dr. Catherine André
Equipe "Génétique du chien"
"Institut de Génétique et Développement de Rennes"
UMR6290-CNRS, Université de Rennes 1
2, Av. Léon Bernard
35043 Rennes cedex
Tel +33 (0)2 23 23 45 09 / 41 75
Fax : +33 (0)2 23 23 44 78
catherine.andre@univ-rennes1.fr
Site du laboratoire : http://igdr.univ-rennes1.fr/
Site "Génétique du chien" : http://dog-genetics.genouest.org
Вкратце
Во Франции удалось создать тест на проверку вероятности заболевания раком Берснских Зенненхундов.
Тест отработан на французском поголовье Бернов.
Французские исследователи-ученые обращаются за помощью ко всем Клубам БЗ мира - собрать образцы крови Бернов и выслать их во Францию для отработки теста для всех Бернов мира.
Иными словами, можно будет сдать кровь, и по крови ученые смогут сказать о вероятности заболевания раком конкретной собаки.
Как вы понимаете, это имеет исключительную важность для дальнейшего разведения породы с учетом повышения продолжительности жизни.
Как нам это сделать в России?? Я пока не знаю. Надо думать всем вместе!
Готов перевести те предложения, которые остались непонятными. Но суть письма я уже передал.